2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-178641
    4'-O-Ac-3'-O-Bz-2'-O-Me-N3-Bz-U
    4'-O-Ac-3'-O-Bz-2'-O-Me-N3-Bz-U is a monomeric raw material that can be used for nucleic acid synthesis.
    4'-O-Ac-3'-O-Bz-2'-O-Me-N3-Bz-U
  • HY-29316
    3'-O-Azidomethylene-dT
    3'-O-Azidomethylene-dT is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-O-Azidomethylene-dT
  • HY-400930
    2',3'-Di-O-iBu-rG(iBu)
    2',3'-Di-O-iBu-rG(iBu) is a monomeric raw material that can be used for nucleic acid synthesis.
    2',3'-Di-O-iBu-rG(iBu)
  • HY-178558
    (2'OMe-5'pp-m6A)pG
    (2'OMe-5'pp-m6A)pG is a monomeric raw material that can be used for nucleic acid synthesis.
    (2'OMe-5'pp-m6A)pG
  • HY-W073825
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine is a 2’-0-(2-methoxyethyl) guanosine derivative. 2’-0-methoxyethyl nucleoside derivatives can enhance the affinity with RNA and increase the resistance of oligonucleotides to nucleases.
    N2-iso-Butyryl-2'-O-(2-methoxyethyl)guanosine
  • HY-115736B
    Xanthosine-5'-triphosphate lithium
    Xanthosine-5'-Triphosphate (5'-XTP) lithium, a nucleotide, is produced by deamination of purine bases. Xanthosine-5'-Triphosphate lithium is a substrate of inosine triphosphate pyrophosphatase (ITPase).
    Xanthosine-5'-triphosphate lithium
  • HY-16445A
    CNDAC
    		Inhibitor
    CNDAC is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC induces DNA damage and apoptosis.
    CNDAC
  • HY-171529
    2′-OMe-UDP
    2′-OMe-UDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    2′-OMe-UDP
  • HY-A0004S
    Decitabine-13C5
    Decitabine-13C5 (5-Aza-2'-deoxycytidine-13C5) is 13C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity.
    Decitabine-<sup>13</sup>C<sub>5</sub>
  • HY-13701R
    Nelarabine (Standard)
    		Inhibitor
    Nelarabine (Standard) is the analytical standard of Nelarabine. This product is intended for research and analytical applications. Nelarabine (506U78) is a nucleoside analogue and can be used for the research of T cell acute lymphoblastic leukemia (T-ALL).
    Nelarabine (Standard)
  • HY-128710R
    2'-Fluorothymidine (Standard)
    2'-Fluorothymidine (Standard) is the analytical standard of 2'-Fluorothymidine. This product is intended for research and analytical applications. 2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine) is a nucleoside analog and hCNT inhibitor, with an IC50 of 1.1 μM against hCNT1 and an IC50 of 9.7 μM against hCNT3. 2'-Fluorothymidine undergoes phosphorylation by cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2). 2'-Fluorothymidine acts as a backbone stabilizer in oligonucleotide synthesis and can also form radiolabeled candidates. 2'-Fluorothymidine is applicable in tumor-related research.
    2'-Fluorothymidine (Standard)
  • HY-154488
    3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine
    3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine is a uridine analog. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    3′-O-[(1,1-Dimethylethyl)dimethylsilyl]-2′-O-methyluridine
  • HY-178678
    3'-ONH₂-dCTP
    3'-ONH?-dCTP is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-ONH₂-dCTP
  • HY-178605
    DMTr-2'-O-Bn-rU-3'-CE-phosphoramidite
    DMTr-2'-O-Bn-rU-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Bn-rU-3'-CE-phosphoramidite
  • HY-178617
    5'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rA(Ac)
    5'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rA(Ac) is a monomeric raw material that can be used for nucleic acid synthesis.
    5'-O-DMTr-2'-O-(2-cyanoethoxymethyl)-rA(Ac)
  • HY-178604
    DMTr-2'-O-Bn-rC(Ac)-3'-CE-phosphoramidite
    DMTr-2'-O-Bn-rC(Ac)-3'-CE-phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-Bn-rC(Ac)-3'-CE-phosphoramidite
  • HY-105336R
    3-Deazauridine (Standard)
    3-Deazauridine (Standard) is the analytical standard of 3-Deazauridine (HY-105336). This product is intended for research and analytical applications. 3-Deazauridine (NSC 126849) is a uridine analogue. 3-Deazauridine competitively inhibits cytidine triphosphate synthase to inhibit the biosynthesis of cytidine-5'-triphosphate. 3-Deazauridine acts synergistically with several antineoplastic agents, acting as a biological response modifier.
    3-Deazauridine (Standard)
  • HY-174108
    3′-O-Azidomethyl-dTTP
    3′-O-Azidomethyl-dTTP is a monomeric raw material that can be used for nucleic acid synthesis.
    3′-O-Azidomethyl-dTTP
  • HY-173170
    Pseudouridine 5'-OTBDPS
    Pseudouridine 5'-OTBDPS (5-(5-O-TBDPS-β-D-ribofuranosyl)uracil) is an intermediate of Pseudouridine (HY-113061).
    Pseudouridine 5'-OTBDPS
  • HY-171534
    LNA-GTP
    LNA-GTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-GTP